Imaging Mass Spectrometry

Imaging Mass Spectrometry

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Addressing the widespread need for a practical guide to imaging mass spectrometry (IMS), this book presents the protocols of IMS technology. As that technology expands, research groups around the world continue its development. Pharmaceutical companies are using IMS for drug analyses to study pharmacokinetics and medical properties of drugs. Drug research and disease-related biomarker screening are experiencing greater use of this technology, with a concurrent increase in the number of researchers in academia and industry interested in wider applications of IMS. Intended for beginners or those with limited experience with IMS technology, this book provides practical details and instructions needed for immediate know-how, including the preparation of animal tissue samples, the application of a matrix, instrumental operations, and data analysis, among others. By describing the foundations of IMS, this volume contributes to the ongoing development of the field and to progress in human health.Protocols for Mass Microscopy Mitsutoshi Setou. Fig. 6.1 Photograph of matrix application instruments. Current matrix application methodologies can be subdivided into manual operating methods (a, b) and automatic methods (c, d) 1. Manual spraying of the matrix solution with an artistic air-brush and thin layer chromatography (TLC) sprayer 2. Automatic depositing of an array of small matrix solution droplets with robotic devices [1, 2] 3. Sublimating the matrices under reducedanbsp;...

Title:Imaging Mass Spectrometry
Author: Mitsutoshi Setou
Publisher:Springer Science & Business Media - 2010-01-29

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