Suicide Gene Therapy

Suicide Gene Therapy

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The first comprehensive review of both the theory and practice of suicide gene therapy. The authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, immunological implications, and its clinical impact. They also describe all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Understand the latest developments in suicide gene therapy Use readily reproducible methods to explore, study, and advance suicide gene therapy Refer to the first book to integrate the theory and practice of suicide gene therapy.In addition to the well-known problems of slow endocytosis and late endosome entrapment (see preceding), there has been ... The diagram is drawn making the assumption that plasmid DNA has been delivered, which is expressed in ananbsp;...

Title:Suicide Gene Therapy
Author: Caroline J. Springer
Publisher:Springer Science & Business Media - 2004-01

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